Article
Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma.
Frontiers in immunology - 1 Jan 2021
Xu Wenhao, Tao Juli, Zhu Wenkai, Liu Wangrui, Anwaier Aihetaimujiang, Tian Xi, Su Jiaqi, Shi Guohai, Huang Haineng, Wei Gaomeng, Li Chuanyu, Qu Yuanyuan, Zhang Hailiang, Ye Dingwei
Abstract excerpt
Interferon-gamma (IFN-γ) has a complex role in modulating the tumor microenvironment (TME) during renal cell carcinoma (RCC) development. To define the role of IFN-γ response genes in RCC progression, we characterized the differential gene expression, prognostic implications, and DNA variation profiles of selected IFN-γ response signatures, which exhibited a significant hazard ratio for the overall survival (OS)...
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