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Article

Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics.

Frontiers in immunology - 1 Jan 2026

Kelchtermans Jelte, Qu Huiqi, Hou Cuiping, Mentch Frank, McGrath-Morrow Sharon A, Hakonarson Hakon

Abstract excerpt

Background: Exposure to fine particulate matter (PM2.5) increases asthma severity and reduces glucocorticoid responsiveness in children, yet the molecular mechanisms underlying PM2.5 sensitivity remain unclear. We previously identified a PM2.5-sensitive asthma phenotype and developed a PM2.5 sensitivity polygenic risk score (sPRS) correlated with asthma exacerbations and lung function decline. Research question:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41710897
DOI: 10.3389/fimmu.2026.1644537
PMCID: PMC12909167

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SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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