Article
Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.
The Journal of allergy and clinical immunology - 1 Oct 2015
Sordillo Joanne E, Kelly Roxanne, Bunyavanich Supinda, McGeachie Michael, Qiu Weiliang, Croteau-Chonka Damien C, Soto-Quiros Manuel, Avila Lydiana, Celedón Juan C, Brehm John M, Weiss Scott T, Gold Diane R, Litonjua Augusto A
Abstract excerpt
BACKGROUND: Gene-environment interaction studies using genome-wide association study data are often underpowered after adjustment for multiple comparisons. Differential gene expression in response to the exposure of interest can capture the most biologically relevant genes at the genome-wide level. OBJECTIVE: We used differential genome-wide expression profiles from the Epidemiology of Home Allergens and Asthma...
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