Article
A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.
EBioMedicine - 1 Jul 2026
Xue Shuangjia, Nouraie Seyed Mehdi, Wang Jiebiao, Li Xingnan, Meyers Deborah, Bleecker Eugene R, Ortega Victor E, Castro Mario, Denlinger Loren C, Erzurum Serpil, Israel Elliot, Woodruff Prescott, Moore Wendy C, Christenson Stephanie, Fahy John, Sumino Kaharu, Jarjour Nizar, Levy Bruce, Wenzel Sally E
Abstract excerpt
BACKGROUND: Asthma is a heterogeneous disease influenced by genetic and environmental factors. Fine particulate matter (PM2.5) exacerbates asthma, likely through oxidative stress pathways, but whether genetic variation modifies this effect remains unclear. METHODS: We analysed data on 948 adults with asthma from the Severe Asthma Research Program (SARP), linking ZIP-code-level PM2.5 exposure with whole-genome...
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