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Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM2.5 polygenic risk score study.

Environmental research - 15 Feb 2025

Kelchtermans Jelte, March Michael E, Mentch Frank, Qu Huiqi, Liu Yichuan, Nguyen Kenny, Hakonarson Hakon

Abstract excerpt

RATIONALE: Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap. OBJECTIVES: To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma. METHODS: We complete a GWAS in pediatric patients with asthma frequently exposed to...

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Identifiers

PMID: 39725137
DOI: 10.1016/j.envres.2024.120666
PMCID: PMC11800831

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