Article

Pathway-based genetic susceptibility and cleaning agent exposures in adult asthma: A semi explorative GxE analysis in the Personalized Environment and Gene Study (PEGS)

2025-06-30

Abstract excerpt

<h4>Background</h4> Pathway-based approaches may effectively dissect the polygenic architecture of complex diseases. We conducted a semi-explorative interaction study between genome-wide and pathway-specific polygenic risk scores (PRS) and occupational asthmagens (i.e., cleaning agents) on adult asthma. <h4>Methods</h4> This study included 2615 adults from the Personalized Environment and Genes Study (PEGS) in Nor...

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Literature Corpus work: ef2d4af6-a03b-54e5-97d0-87330c261b67
DOI: 10.1101/2025.06.29.25330505

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