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Article

DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2026

Li Jenny Z, Ricarte-Filho Julio C, Isaza Amber R, Hinkle Kyle, Xu Feng, Li Marilyn M, Bauer Andrew J, Franco Aime T, Zhou Wanding

Abstract excerpt

PURPOSE: Accurate assessment of invasiveness in pediatric thyroid carcinomas is essential to prevent unnecessary surgery and avoid surgery-associated complications. DNA methylation, a proven molecular biomarker for cancer classification, holds promise for stratifying thyroid cancer risk. The objectives were to determine the epigenetic hallmarks of pediatric thyroid carcinomas and investigate whether DNA methylome...

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Topics

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Share to Adenocarcinoma, Follicular
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Lymphatic Metastasis

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41701943
DOI: 10.1158/1078-0432.CCR-25-2109
PMCID: PMC13059138

Genes

BRAF
DICER1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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