MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor subtypes

Abstract excerpt

BACKGROUND: Classification of pediatric tumors into biologically defined subtypes is challenging, and multifaceted approaches are needed. For this aim, we developed a diagnostic classifier based on DNA methylation profiles. RESULTS: Methylation data generated by the Illumina Infinium HumanMethylation 450 BeadChip arrays were downloaded from the Gene Expression Omnibus (n = 472). Using the data, we built MethPed,...

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