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Article

Evaluation of the genetic alterations landscape of differentiated thyroid cancer in children.

Journal of pediatric endocrinology & metabolism : JPEM - 17 Dec 2025

Çetiner Ebru Barsal, Özcan Mualla, Aydemir Mustafa, Donbaloğlu Zeynep, Singin Berna, Behram Bilge Aydın, Bedel Aynur, Ocak Güzide Ayşe, Gürer İnanç Elif, Karagüzel Güngör, Parlak Mesut, Tuhan Hale

Abstract excerpt

OBJECTIVES: Studies investigating the underlying genetic profile in pediatric patients diagnosed with differentiated thyroid cancer (DTC) are quite limited. This study aimed to identify genetic alterations in patients diagnosed with DTC. METHODS: A total of 20 patients with confirmed DTC were included in the study; however, five were excluded due to the unavailability of thyroid tumor samples. Somatic mutation...

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Identifiers

PMID: 41176785
DOI: 10.1515/jpem-2025-0443

Genes

NRAS
BRAF
DICER1
ETV6
NTRK3
RET
ALK
HRAS
KRAS

Variants

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