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DNA Methylation Signatures Identify Biologically Distinct Thyroid Cancer Subtypes

11 May 2013

Abstract excerpt

OBJECTIVE: The purpose of this study was to determine the global patterns of aberrant DNA methylation in thyroid cancer. RESEARCH DESIGN AND METHODS: We have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of papillary, follicular, medullary, and anaplastic thyroid tumors. RESULTS: We identified 262 and 352 hypermethylated and 13 and 21 hypomethylated...

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PMID: 23666970
DOI: 10.1210/jc.2012-3566

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