Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.

doi:10.1002/alz.71219

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Article

Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Cao Han, Zheng Ziyu, Zhou Xiaopu, Kikuchi Masataka, Wong Hiu Yi, Cheng Elaine Y L, Wong Bonnie W Y, Lo Ronnie M N, Shoai Maryam, Chong Joyce R, Chan Andrew L T, Chen Christopher, Lam Linda C W, Mok Vincent C T, Kwok Timothy C Y, Chen Yu, Ip Fanny C F, Mok Kin Y, Miyashita Akinori, Ikeuchi Takeshi, Hardy John, Fu Amy K Y, Ip Nancy Y

Abstract excerpt

INTRODUCTION: Genome-wide association studies have identified numerous Alzheimer's disease (AD) susceptibility loci in European populations. However, the genetic architecture of AD in non-European populations remains underinvestigated. METHODS: We performed a genetic association study in East Asians (N = 8514) to validate known AD loci and identify new susceptibility loci. RESULTS: We identified LILRB2-LILRB5 as...

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Identifiers

PMID: 41700061
DOI: 10.1002/alz.71219
PMCID: PMC12910251

Genes

LILRB2
LILRB5
FAM135A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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