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Article

A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.

Molecular medicine (Cambridge, Mass.) - 6 Mar 2025

Mitsumori Risa, Asanomi Yuya, Morizono Takashi, Shigemizu Daichi, Niida Shumpei, Ozaki Kouichi

Abstract excerpt

BACKGROUND: Dementia with Lewy bodies (DLB) is the second most common type of degenerative dementia in older patients. As with other multifactorial diseases, the pathogenesis results from interactions of environmental and genetic factors. The genetic basis of DLB is not yet fully understood. Recent genomic analyses of DLB in Caucasian cohorts identified genetic susceptibility loci for DLB, but the comprehensive...

Read the complete abstract on PubMed

Topics

Aged
Aged, 80 and over
Female
Humans
Male
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

East Asian People

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Japan

Lewy Body Disease

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40045203
DOI: 10.1186/s10020-025-01115-7
PMCID: PMC11884146

Genes

APOE
DHTKD1
GPRIN3
ICOS
PARD3B
SEC61A2
SNCA
ZNF155
ZNF284

Provenance

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