IFNL4 genotype is associated with hepatitis A virus infection findings from a focused phenotype study in the UK Biobank Cohort.

doi:10.1016/j.ijid.2026.108483

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Article

IFNL4 genotype is associated with hepatitis A virus infection findings from a focused phenotype study in the UK Biobank Cohort.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2026

Agarwala Neha, Song Minkyo, Ghany Marc G, Hubbard Aubrey K, Wheeler William, Engels Eric, Prokunina-Olsson Ludmila, Machiela Mitchell J, Pfeiffer Ruth M, O'Brien Thomas R

Abstract excerpt

BACKGROUND: The IFNL4-ΔG/TT (rs368234815) polymorphism controls production of the IFN-λ4 protein; the IFNL4-ΔG allele generates IFN-λ4, IFNL4-TT disrupts IFN-λ4 production. Individuals who carry IFNL4-ΔG have impaired clearance of hepatitis C virus (HCV), but less hepatic inflammation in the face of chronic hepatitis C. OBJECTIVE: To conduct a focused phenotype association study to identify additional...

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PMID: 41698497
DOI: 10.1016/j.ijid.2026.108483

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