Article
Gender-dependent multiple cross-phenotype association of interferon lambda genetic variants with peripheral blood profiles in healthy individuals.
Molecular genetics & genomic medicine - 1 Jan 2024
Roy Debarati Guha, Singh Lucky, Chaturvedi Himanshu K, Chinnaswamy Sreedhar
Abstract excerpt
BACKGROUND: Type III interferons (IFN), also called as lambda IFNs (IFN-λs), are antiviral and immunomodulatory cytokines that are evolutionarily important in humans. Given their central roles in innate immunity, they could be influencing other aspects of human biology. This study aimed to examine the association of genetic variants that control the expression and/or activity of IFN-λ3 and IFN-λ4 with multiple...
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