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Bilateral risk reducing mastectomy uptake trends in healthy BRCA1/2 mutation carriers of an European City, the brachoice study.

World journal of surgical oncology - 28 May 2026

Bernini Marco, Innocenti Sofia, Turchetti Daniela, Miccoli Sara, Innella Giovanni, Pellegrini Alice, Melina Marica, Zanotti Simone, Cucchi Maria Cristina, Galluzzo Valentina, Lozano Miralles Maria Elisa, Ventimiglia Fabrizio, Cocchi Daniela, Serra Margherita

Abstract excerpt

This study evaluates the uptake of bilateral risk-reducing mastectomy (BRRM) among unaffected BRCA1/2 mutation carriers in the metropolitan area of Bologna, Italy, between 2012 and 2024. Pathogenic BRCA variants, which confer a markedly increased lifetime risk of breast cancer, are managed through preventive strategies such as BRRM, which can reduce risk by more than 90%.Among 178 women (89 BRCA1 and 89 BRCA2...

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Identifiers

PMID: 42210211
DOI: 10.1186/s12957-026-04400-9
PMCID: PMC13403854

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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