Effects of chemotherapy on contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers: A nationwide cohort study.

doi:10.1016/j.breast.2021.12.007

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Effects of chemotherapy on contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers: A nationwide cohort study.

Breast (Edinburgh, Scotland) - 1 Feb 2022

Akdeniz Delal, van Barele Mark, Heemskerk-Gerritsen Bernadette A M, Steyerberg Ewout W, Hauptmann Michael, van de Beek Irma, van Engelen Klaartje, Wevers Marijke R, Gómez García Encarnacion B, Ausems Margreet G E M, Berger Lieke P V, van Asperen Christi J, Adank Muriel A, Collée Margriet J, Stommel-Jenner Denise J, Jager Agnes, Schmidt Marjanka K, Hooning Maartje J

Abstract excerpt

AIM: BRCA1/2 mutation carriers with primary breast cancer (PBC) are at high risk of contralateral breast cancer (CBC). In a nationwide cohort, we investigated the effects of chemotherapeutic agents given for PBC on CBC risk separately in BRCA1 and BRCA2 mutation carriers. PATIENTS AND METHODS: BRCA1 or BRCA2 mutation carriers with an invasive PBC diagnosis from 1990 to 2017 were selected from a Dutch cohort. We...

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Identifiers

PMID: 34929424
DOI: 10.1016/j.breast.2021.12.007
PMCID: PMC8693290

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