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Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma

1 Jan 2021

Abstract excerpt

Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict thesensitivity of IDH-wildtype glioblastoma to temozolomide therapy. Given that the IDH status has critical effects on the survival andepigenetic features of glioblastoma, we aimed to assess the role of MGMT promoter methylation in IDH-mutant glioblastoma. Methods: This study included 187 IDH-mutant...

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PMID: 33628600
DOI: 10.20892/j.issn.2095-3941.2020.0179

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