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DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation

10 Jan 2023

Abstract excerpt

Introduction: Homeodomain-interacting protein kinase 3 (HIPK3) plays an important role in cell proliferation, apoptosis, and inflammation. Over-expression of HIPK3 in immune cells in rheumatoid arthritis (RA) has been reported. In this study, we investigated blood methylation levels and clinical characteristics of RA in a Chinese population. Methods: A total of 235 patients with RA, 30 with osteoarthritis (OA),...

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PMID: 36703984
DOI: 10.3389/fimmu.2022.1087279

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