Article

Hypomethylation of the <em>Dual Specificity Phosphatase</em> (<em>DUSP22</em>) Promoter in Cell-Free DNA (cf-DNA) Is Associated with Rheumatoid Arthritis and Joint Space Narrowing

2025-09-09

Abstract excerpt

<h4>Background: </h4> /Objective: While several advances have been made in the last decade, reliable biomarkers for diagnosis, prognosis, and especially for the treatment of rheumatoid arthritis (RA) have yet to be identified. In previous studies, DUSP22 DNA methylation changes were found to be associated with RA and erosive disease. We conducted a pilot study to investigate plasma cell-free DNA (cfDNA) methylatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5cf8476-7b52-50b7-9778-ffe9660d8f0f
DOI: 10.20944/preprints202509.0722.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypomethylation of the <em>Dual Specificity Phosphatase</em> (<em>DUSP22</em>) Promoter in Cell-Free DNA (cf-DNA) Is Associated with Rheumatoid Arthritis and Joint Space NarrowingDOI 10.20944/preprints202509.0722.v1Read

Hypomethylation of CYP 2E1 and DUSP 22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis PatientsSemantic proximity Read

DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid ArthritisSemantic proximity Read

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide StudySemantic proximity Read

Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid ArthritisSemantic proximity Read

Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onsetSemantic proximity Read

Cell-Free DNA in Rheumatoid ArthritisSemantic proximity Read

Identification of Specific Joint-Inflammatogenic Cell-Free DNA Molecules From Synovial Fluids of Patients With Rheumatoid ArthritisSemantic proximity Read

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencingSemantic proximity Read

Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals.Semantic proximity Read

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritisSemantic proximity Read

Differential CpG DNA methylation in peripheral naïve CD4+ T-cells in early rheumatoid arthritis patientsSemantic proximity Read

Correlation analysis of circulating PCDH17 DNA methylation changes with rheumatoid arthritis patientsSemantic proximity Read