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Article

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.

The Journal of experimental medicine - 29 Sept 2008

Chen Chong, Liu Yu, Liu Runhua, Ikenoue Tsuneo, Guan Kun-Liang, Liu Yang, Zheng Pan

Abstract excerpt

The tuberous sclerosis complex (TSC)-mammalian target of rapamycin (mTOR) pathway is a key regulator of cellular metabolism. We used conditional deletion of Tsc1 to address how quiescence is associated with the function of hematopoietic stem cells (HSCs). We demonstrate that Tsc1 deletion in the HSCs drives them from quiescence into rapid cycling, with increased mitochondrial biogenesis and elevated levels of...

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Source

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Identifiers

PMID: 18809716
DOI: 10.1084/jem.20081297
PMCID: PMC2556783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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