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mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction

26 Jul 2024

Abstract excerpt

Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a master metabolic regulator that is active in nearly all proliferating eukaryotic cells; however, it is unclear whether mTORC1 activity changes throughout the cell cycle. We find that mTORC1 activity oscillates from lowest in mitosis/G1 to highest in S/G2. The interphase oscillation is mediated through the TSC complex but is independent of major known...

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PMID: 39067023
DOI: 10.1016/j.celrep.2024.114543

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