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Article

MTG2 as a Causal and Druggable Target in Uveal Melanoma via Mitochondrial DNA Dynamics: Evidence From Functional Validation and DMSA Identification.

Investigative ophthalmology & visual science - 2 Feb 2026

Zhang Yan, Min Daliu, Wang Yonggang, Yu Wenxi, Cui Bowen, Su Yuying, Shen Zan, Feng Changzhou

Abstract excerpt

Purpose: Mitochondrial dysfunction is increasingly recognized as a pivotal factor in cancer pathogenesis. We thus explored the causal role of mitochondrial-related genes (MRGs) in uveal melanoma (UM) and the underlying mechanisms. Methods: We performed Mendelian randomization (MR) analysis using 1693 cis-expression quantitative trait loci (cis-eQTLs) of MRGs as instrumental variables and genome-wide association...

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Share to Cell Proliferation
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Quantitative Trait Loci

Share to Tumor Suppressor Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 41677388
DOI: 10.1167/iovs.67.2.30
PMCID: PMC12908717

Genes

MTG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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