Article
In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2022
Piaggio Francesca, Croce Michela, Reggiani Francesco, Monti Paola, Bernardi Cinzia, Ambrosio Marianna, Banelli Barbara, Dogrusöz Mehmet, Jockers Ralf, Bordo Domenico, Puzone Roberto, Viaggi Silvia, Coviello Domenico, Lanza Francesco B, Bartolucci Martina, Petretto Andrea, Mosci Carlo, Gangemi Rosaria, van der Velden Pieter A, Jager Martine J, Pfeffer Ulrich, Amaro Adriana
Abstract excerpt
BACKGROUND AND AIM OF THE STUDY: Mutations in the Gα-genes GNAQ and GNA11 are found in 85-90% of uveal melanomas (UM). Aim of the study is to understand whether the mutations in both genes differentially affect tumor characteristics and outcome and if so, to identify potential mechanisms. METHODS: We analyzed the association between GNAQ and GNA11 mutations with disease-specific survival, gene expression...
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