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Article

R-loop-associated regulator VDAC1 drives malignant phenotypes in uveal melanoma.

Experimental eye research - 1 Sept 2026

Gao Liyuan, Wei Rongrong

Abstract excerpt

BACKGROUND: R-loops regulate genome stability and transcription, but their roles in uveal melanoma (UVM) are unclear. METHODS: A total of 1185 R-loop regulators were analyzed across TCGA-UVM and GEO cohorts. We utilized ssGSEA to assess global R-loop activity and conducted integrative bioinformatic screening to identify key regulators associated with poor prognosis and metastasis. The study focused on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42203013
DOI: 10.1016/j.exer.2026.111087

Genes

VDAC1
H2AX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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