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Article

Ferroptosis dysregulation, mitochondrial dysfunction, and iron metabolism alterations are correlated with aggressiveness in uveal melanoma.

Apoptosis : an international journal on programmed cell death - 10 Jan 2026

Singh Lata, Kumar Nikhil, Supriya Manisha, Kashyap Seema, Sawant Athang, Sen Seema, Chawla Bhavna, Lomi Neiwete, Bakhshi Sameer, Nag Tapas Chandra, Panwar Chanda, Singh Mithalesh Kumar

Abstract excerpt

To elucidate the dysregulation of ferroptosis in uveal melanoma (UM), a comprehensive understanding is required of the expression patterns of ferroptosis-related genes, their association with key driver mutations and clinicopathological features, and their prognostic significance in UM patients. We analyzed tumor tissues from 56 UM enucleated eyeballs using qRT-PCR, immunohistochemistry, and western blotting to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41518375
DOI: 10.1007/s10495-025-02205-x

Genes

GPX4
SLC7A11
ACSL4
BAP1
CISD1
LPCAT3
SLC3A2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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