Analysis of the Expression and Single-Nucleotide Variant Frequencies of the Butyrophilin-like 2 Gene in Patients With Uveal Melanoma.

doi:10.1001/jamaophthalmol.2016.2691

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Article

Analysis of the Expression and Single-Nucleotide Variant Frequencies of the Butyrophilin-like 2 Gene in Patients With Uveal Melanoma.

JAMA ophthalmology - 1 Oct 2016

Amaro Adriana, Parodi Federica, Diedrich Konrad, Angelini Giovanna, Götz Cornelia, Viaggi Silvia, Maric Irena, Coviello Domenico, Pistillo Maria Pia, Morabito Anna, Mandalà Mario, Ghiorzo Paola, Visconti Paola, Gualco Marina, Anselmi Luca, Puzone Roberto, Lanza Francesco, Mosci Carlo, Raggi Federica, Bosco Maria Carla, Varesio Luigi, Zeschnigk Michael, Spano Laura, Queirolo Paola, Pfeffer Ulrich

Abstract excerpt

IMPORTANCE: Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of metastasis conferred by chromosome 3 monosomy. Chromosome 6p contains several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is associated with prostate cancer risk and autoimmune diseases. OBJECTIVE: To investigate...

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Identifiers

PMID: 27532663
DOI: 10.1001/jamaophthalmol.2016.2691

Genes

BTNL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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