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Astrocytic IGF‐1 and IGF‐1R Orchestrate Mitophagy in Traumatic Brain Injury via Exosomal miR‐let‐7e

1 Jan 2022

Abstract excerpt

Defective brain hormonal signaling and autophagy have been associated with neurodegeneration after brain insults, characterized by neuronal loss and cognitive dysfunction. However, few studies have linked them in the context of brain injury. Insulin‐like growth factor‐1 (IGF‐1) is an important hormone that contributes to growth, cell proliferation, and autophagy and is also expressed in the brain. Here, we...

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PMID: 36062186
DOI: 10.1155/2022/3504279

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