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Article

Apolipoprotein E Isoform-specific changes related to stress and trauma exposure.

Translational psychiatry - 28 Mar 2022

Torres Eileen Ruth S, Luo Jenny, Boehnlein James K, Towns Daniel, Kinzie J David, DeBarber Andrea E, Raber Jacob

Abstract excerpt

Post-Traumatic Stress Disorder (PTSD) is a highly prevalent mental health disorder. Due to the high level of variability in susceptibility and severity, PTSD therapies are still insufficient. In addition to environmental exposures, genetic risks play a prominent role and one such factor is apolipoprotein E. The protein (apoE) is functionally involved in cholesterol transport and metabolism and exists as 3 major...

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PMID: 35347119
DOI: 10.1038/s41398-022-01848-7
PMCID: PMC8960860

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