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Article

A radical transfer pathway in spore photoproduct lyase.

Biochemistry - 7 May 2013

Yang Linlin, Nelson Renae S, Benjdia Alhosna, Lin Gengjie, Telser Joshua, Stoll Stefan, Schlichting Ilme, Li Lei

Abstract excerpt

Spore photoproduct lyase (SPL) repairs a covalent UV-induced thymine dimer, spore photoproduct (SP), in germinating endospores and is responsible for the strong UV resistance of endospores. SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-4S](+) cluster to reduce SAM, generating a catalytic 5'-deoxyadenosyl radical (5'-dA(•)). This in turn abstracts a H atom from SP, generating an SP...

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Identifiers

PMID: 23607538
DOI: 10.1021/bi3016247
PMCID: PMC3666868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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