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Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link.

Biochemistry - 12 Apr 2016

Bruender Nathan A, Wilcoxen Jarett, Britt R David, Bandarian Vahe

Abstract excerpt

Peptide-derived natural products are a class of metabolites that afford the producing organism a selective advantage over other organisms in their biological niche. While the polypeptide antibiotics produced by the nonribosomal polypeptide synthetases (NRPS) are the most widely recognized, the ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emerging group of natural products with...

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Identifiers

PMID: 27007615
DOI: 10.1021/acs.biochem.6b00145
PMCID: PMC4829460

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