Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.

Abstract excerpt

N-methylation of nucleic acids, proteins, and peptides is a chemical modification with significant impact on biological regulation. Despite the simplicity of the structural change, N-methylation can influence diverse functions including epigenetics, protein complex formation, and microtubule stability. While there are limited examples of N-methylation of the α-amino group of bacterial and eukaryotic proteins,...

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