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Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations

10 Aug 2022

Abstract excerpt

The incidence of cutaneous T-cell lymphoma (CTCL) increases with age, and blood involvement portends a worse prognosis. To advance our understanding of the development of CTCL and identify potential therapeutic targets, we performed integrative analyses of paired single-cell RNA and T-cell receptor (TCR) sequencing of peripheral blood CD4+ T cells from patients with CTCL to reveal disease-unifying features. The...

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PMID: 35947128
DOI: 10.1182/bloodadvances.2022008168

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