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Article

Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression.

Genome medicine - 2 Apr 2024

Chen Zegeng, Huang He, Hong Huangming, Huang Huageng, Weng Huawei, Yu Le, Xiao Jian, Wang Zhao, Fang Xiaojie, Yao Yuyi, Yue Jia-Xing, Lin Tongyu

Abstract excerpt

BACKGROUND: Natural killer/T cell lymphoma (NKTCL) is a clinically and genetically heterogeneous disease with poor prognosis. Genome sequencing and mutation characterization provides a powerful approach for patient stratification, treatment target discovery, and etiology identification. However, previous studies mostly concentrated on base-level mutations in primary NKTCL, whereas the large-scale genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38566223
DOI: 10.1186/s13073-024-01324-5
PMCID: PMC10986005

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