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Article

DNMT3A p.R882C driven proliferation and anti-apoptotic effects in pancreatic cancer cells.

Scientific reports - 7 Feb 2026

Qu Zhen, Mao Jinglin, Qian Yang, Cao Jingyu, Jiang Shulong

Abstract excerpt

Pancreatic cancer, one of the most lethal malignancies, is characterized by insidious onset, frequent late-stage diagnosis, rapid progression, and limited surgical opportunities. Pancreatic ductal adenocarcinoma (PDAC), accounting for over 90% of pancreatic cancer cases, remains a therapeutic challenge due to the scarcity of effective targeted therapies. In this study, we collected formalin-fixed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41652067
DOI: 10.1038/s41598-026-38613-5
PMCID: PMC12946168

Genes

DNMT3A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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