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Article

DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications

5 Jun 2020

Abstract excerpt

BACKGROUND: Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the leading causes of cancer-related deaths in both genders. Epigenetic alterations may lead to the suppression of tumor suppressor genes, and DNA methylation is a predominant epigenetic modification. DNA methyltransferase 1 (DNMT1) is required...

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PMID: 32504382
DOI: 10.1007/s13402-020-00526-4

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