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Article

Polarising SNPs Without Outgroup.

Molecular ecology resources - 1 Feb 2026

Liang Jinyang, Dutheil Julien Y

Abstract excerpt

Asserting which allele is ancestral or derived, known as polarisation, is a prerequisite of many population and quantitative genetic methods. One important application is the inference of the unfolded site-frequency spectrum (uSFS). The most widely used approaches are based on outgroup data. However, for studies on species with only distantly related outgroups, large divergence between the ingroup and outgroup...

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PMID: 41645964
DOI: 10.1111/1755-0998.70105
PMCID: PMC12878804

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