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Article

Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2015

Wu Sijia, Bellve Karl D, Fogarty Kevin E, Melikian Haley E

Abstract excerpt

The dopamine (DA) transporter (DAT) facilitates high-affinity presynaptic DA reuptake that temporally and spatially constrains DA neurotransmission. Aberrant DAT function is implicated in attention-deficit/hyperactivity disorder and autism spectrum disorder. DAT is a major psychostimulant target, and psychostimulant reward strictly requires binding to DAT. DAT function is acutely modulated by dynamic membrane...

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Source

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Identifiers

PMID: 26621748
DOI: 10.1073/pnas.1512957112
PMCID: PMC4687542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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