Article
Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.
Molecular psychiatry - 1 Jun 2026
Chen Xiaohua, Liu Huan, Liu Yurong, Zhang Cong, Ren Yimeng, Liu Pengcheng, Zhang Shanshan, Li Congjiao, Shen Qian, Wang Siyue, Zhang Chenhui, Wang Qing, Chen Xiangli, Qu Ying, Huang Mengjie, Tang Jie, Liu Xin, Gao Wenzhen, Zhong Rong
Abstract excerpt
Although immune-mediated diseases (IMDs) and major depressive disorder (MDD) commonly co-occur, the bidirectional relationship between them remains to be fully elucidated. Using data from the prospective UK Biobank cohort, we evaluated the bidirectional associations by time-varying Cox proportional hazards regression models and assessed shared genetic architecture using genome-wide association study summary...
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