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A genome-wide cross-trait analysis characterizes the shared genetic architecture between rheumatoid arthritis and psychiatric disorders.

Rheumatology (Oxford, England) - 1 Aug 2026

Ke Xin, Yao Shi, Zheng Xi, Wu Hao, Liu Tian-Yue, Yang Feng-Fan, Zhang Kui, Zheng Zhao-Hui, Zhu Ping

Abstract excerpt

OBJECTIVES: Patients with RA have a 2- to 3-fold elevated risk of psychiatric disorders, suggesting an underlying genetic link between these phenotypes. However, the shared genetic architectures and pathological mechanisms driving RA-psychiatric disorder comorbidity remain to be fully elucidated. Herein, we performed cross-trait analysis to investigate the shared genetic architecture between RA and psychiatric...

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Identifiers

PMID: 42525381
DOI: 10.1093/rheumatology/keag387

Genes

RHOA
TRAF3

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