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Article

Evaluating alloimmunization risk in patients with sickle cell disease and in prenatal care patients with RHCE variants.

Vox sanguinis - 1 May 2026

Leiva-Torres Gabriel André, Baillargeon Nadia, Constanzo-Yanez Jessica, Robitaille Nancy

Abstract excerpt

BACKGROUND AND OBJECTIVES: Clinically significant alloantibodies complicate transfusion and prenatal care, especially in individuals with genetic variants affecting high-frequency antigens. Many patients from African descent carry RHCE*ceVS alleles, which alter the expression of c (RH4), e (RH5) and hrB (RH31). However, the risk and clinical impact of alloimmunization remain uncertain. We evaluated the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41633798
DOI: 10.1111/vox.70193

Genes

SCD
RHCE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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