Article
Analysis of RhCE variants among 806 individuals in France: considerations for transfusion safety, with emphasis on patients with sickle cell disease.
Transfusion - 1 Jun 2011
Pham Bach-Nga, Peyrard Thierry, Juszczak Genevieve, Beolet Marylise, Deram Geneviève, Martin-Blanc Stéphanie, Dubeaux Isabelle, Roussel Michèle, Kappler-Gratias Sandrine, Gien Dominique, Poupel Sylvie, Rouger Philippe, Le Pennec Pierre-Yves
Abstract excerpt
BACKGROUND: DNA testing has enabled the documenting of numerous variants of RHCE alleles, especially in individuals of African origin. The risk for production of clinically significant alloantibodies to Rh antigens of patients carrying variant RHCE alleles has led us to analyze the different RhCE variants investigated by molecular biology. Alloimmunization was analyzed regarding the RHCE genetic profile. STUDY...
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