Article
Utilising red cell antigen genotyping and serological phenotyping in sickle cell disease patients to risk-stratify patients for alloimmunisation risk.
Transfusion medicine (Oxford, England) - 1 Aug 2020
Shih Andrew W, Yan Matthew T S, Elahie Allahna L, Barty Rebecca L, Liu Yang, Berardi Philip, Azzam Mona, Siddiqui Reda, Parvizian Michael K, Mcdougall Tara, Heddle Nancy M, Al-Habsi Khalid S, Goldman Mindy, Cote Jacqueline, Athale Uma, Verhovsek Madeleine M
Abstract excerpt
BACKGROUND: Alloimmunisation and haemolytic transfusion reactions (HTRs) can occur in patients with sickle cell disease (SCD) despite providing phenotype-matched red blood cell (RBC) transfusions. Variant RBC antigen gene alleles/polymorphisms can lead to discrepancies in serological phenotyping. We evaluated differences between RBC antigen genotyping and phenotyping methods and retrospectively assessed if...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.