Article
Clinically relevant RHD-CE genotypes in patients with sickle cell disease and in African Brazilian donors.
Blood transfusion = Trasfusione del sangue - 1 Sept 2016
Gaspardi Ane C, Sippert Emília A, De Macedo Mayra Dorigan, Pellegrino Jordão, Costa Fernando F, Castilho Lilian
Abstract excerpt
BACKGROUND: As a consequence of the homology and opposite orientation of RHD and RHCE, numerous gene rearrangements have occurred in Africans and resulted in altered RH alleles that predict partial antigens, contributing to the high rate of Rh alloimmunisation among patients with sickle cell disease (SCD). In this study, we characterised variant RH alleles encoding partial antigens and/or lacking high prevalence...
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