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Article

A FEN1-EDCR dual-amplification strategy for ultrasensitive detection of CHCHD10 c.176C>T mutation.

Biosensors & bioelectronics - 15 May 2026

Pan Han, Chao Murilege, He Miao, Chen Jinhua, Yin Feifan, Cai Yongliang, Cheng Wenting, Wang Zhongyun, Xiang Yang

Abstract excerpt

A single-base mutation in the CHCHD10 gene can impair thermogenic responses, and inhibit the efficient conversion of white adipose tissue to beige adipose tissue. However, achieving high-fidelity detection of such low-abundance single nucleotide polymorphisms (SNPs) within complex biological matrices remains a critical technological challenge. This study developed a novel method for detecting a single-base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41633268
DOI: 10.1016/j.bios.2026.118468

Genes

CHCHD10
CS
FEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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