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Accurate genotyping of fragmented DNA using a toehold assisted padlock probe.

Biosensors & bioelectronics - 1 May 2021

Gao Yanmin, Qiao Hongyan, Pan Victor, Wang Zhaoguan, Li Jiaojiao, Wei Yanan, Ke Yonggang, Qi Hao

Abstract excerpt

Fragmented DNA from blood plasma, i.e., cell-free DNA, has received great interest as a noninvasive diagnostic biomarker for "point-of-care" testing or liquid biopsy. Here, we present a new approach for accurate genotyping of highly fragmented DNA. Based on toehold-mediated strand displacement, a toehold-assisted padlock probe and toehold blocker were designed and demonstrated with new controllability in...

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PMID: 33636500
DOI: 10.1016/j.bios.2021.113079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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