Article
Prediction of recent HIV-1 infections using Shannon entropy analysis of HIV-1 group-specific antigen protein sequence.
Virology journal - 2 Feb 2026
Fortuin Tumelo L, Nkone Paballo, Loubser Shayne, Tiemessen Caroline T, Mayaphi Simnikiwe H
Abstract excerpt
BACKGROUND: Avidity assays often misclassify chronic HIV-1 infection as recent HIV-1 infection (false recency rate), especially in participants on antiretroviral therapy. The aim of this study was to use Shannon entropy to evaluate HIV-1 group-specific antigen (Gag) sequence diversity for the prediction of recent HIV-1 infections. METHODS: This was a retrospective study that characterised the complete HIV-1 Gag...
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