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In silico structural analysis of EthA substitutions for ranking priority mutations leading to ethionamide resistance in <i>Mycobacterium tuberculosis</i>

2026-04-17

Abstract excerpt

<h4>Background</h4> Tuberculosis (TB) is the second-leading cause of deaths from infectious agents and remains a global health threat. Ethionamide (ETH) is a prodrug used in regimens for multidrug-resistant TB, and, partly due to side effects that can lead to low treatment adhesion, resistance arises. Changes in EthA, the monooxygenase that activates ETH, are the main mechanism of resistance. Yet, of hundreds of...

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Literature Corpus work
b54683b3-6f62-5056-b5c5-c2a78de4315b
DOI
10.64898/2026.04.16.718980
Open publication

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In silico structural analysis of EthA substitutions for ranking priority mutations leading to ethionamide resistance in <i>Mycobacterium tuberculosis</i>DOI 10.64898/2026.04.16.718980
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