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Article

Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen.

Alzheimer's research & therapy - 2 Feb 2026

Valencia-Olvera Ana C, Marottoli Felecia M, Ratia Kiira, Thatcher Gregory Rj, Tai Leon Maing

Abstract excerpt

BACKGROUND: Published data suggest that compared to APOE3, APOE4 could increase the risk of neurodegeneration via higher cerebrovascular permeability. We recently proposed the concept that brain endothelial cell APOE is protective for cerebrovascular function in a genotype specific manner, APOE3 > APOE4, and therefore APOE4 brain endothelial cells may be predisposed to dysfunction during aging and disease. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41622232
DOI: 10.1186/s13195-026-01960-6
PMCID: PMC12964606

Genes

APOE
AXL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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