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Article

[SOX4 drives the differentiation of CD4+T cells toward an immunosuppressive phenotype].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Feb 2026

Zhang Yuelu, Tao Ziqi, Huang Xi, Liu Zhijie, Dong Yiyang, Zhou Lingfei, Huang Menghui, Wang Fang

Abstract excerpt

Objective To investigate the regulatory effects of the SRY-box transcription factor 4 (SOX4) on differentiation and oxidative phosphorylation (OXPHOS) metabolism of CD4+T cells. Methods CD4+T cells were isolated from healthy human peripheral blood using magnetic bead sorting. After stimulation with CD3 and CD28 antibodies for two days, CD4+T cells were infected with lentivirus to establish the SOX4-overexpression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41620962

Genes

SOX4
CD4
FOXP3
CD28
SMAD2
SMAD3
SMAD4
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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