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Article

A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol.

EBioMedicine - 1 Feb 2026

Förster Franz, Horn Katrin, Pott Janne, Delgado Graciela E, Kleber Marcus E, März Winfried, Moissl-Blanke Angela Patricia, Silbernagel Günther, Waldenberger Melanie, Grallert Harald, Peters Annette, Gieger Christian, Baber Ronny, Kirsten Holger, Loeffler Markus, Isermann Berend, Thiery Joachim, Kovacs Peter, Tönjes Anke, Stumvoll Michael, Gylling Helena, Kähönen Mika, Lehtimäki Terho, Mishra Pashupati Prasad, Raitakari Olli, Ceglarek Uta, Scholz Markus

Abstract excerpt

BACKGROUND: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors from de novo biosynthesis. METHODS: We conducted a genome-wide association meta-analysis, combining data from KORA, LIFE-Heart, LIFE-Adult, LURIC, the Sorbs study, and YFS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41619350
DOI: 10.1016/j.ebiom.2026.106144
PMCID: PMC12876664

Genes

CAD
CYP51A1
HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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